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KMID : 1059520110550040650
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Journal of the Korean Chemical Society
2011 Volume.55 No. 4 p.650 ~ p.655
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New Antibacterial Peptide Analogs of 5-Aminobenzimidazoles
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Humaira Y. Gondal
Muhammad Ali
Mashooda H
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Abstract
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Three new peptide analogs 5a-c were obtained through coupling of 5-Amino benzimidazoles 2a-c with L-phenylalanine. For the purpose α-amino group was blocked with phthalic anhydride and activation of α-carboxy group of phenylalanine was carried out by preparing phthaloyl-L-phenylalanyl chloride 4. After developing a successful peptide linkage, the phthaloyl group was removed by treating 5a-c with hydrazine hydrate to get free peptides 6a-c, purified through a column of Amberlite (IR-4B). All of these compounds 2a-c and 5,6a-c have been characterized on the basis of their IR, 1H NMR and EIMS analyses. Antibacterial activity of these compounds is also been reported.
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KEYWORD
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benzimidazoles, L-phenylalanine, peptide, antibacterial
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